Quasi-Mendelian Paternal Inheritance of mitochondrial DNA: A notorious artifact, or anticipated mtDNA behavior?

https://www.biorxiv.org/content/10.1101/660670v1?ct=

Sofia Annis, Zoe Fleischmann, Mark Khrapko, Melissa Franco, Kevin Wasko, Dori Woods, Wolfram S. Kunz, Peter Ellis, Konstantin Khrapko

• A recent publication suggested that biparental inheritance of mtDNA may sometimes occur in humans
• It has since been suggested that these observations may be explained by the presence of mtDNA nuclear pseudogenes (NUMTs) in the father's nuclear genome, rather than biparental inheritance
• The authors of this article suggest another interpretation: that the original authors did in fact observe biparental inheritance of mtDNA, and that the paternal mtDNA was inherited by nascent cells with low copy number, and that the paternal mtDNA had a selective advantage. 
• Using computational modelling (based on this publication), the authors predict a somatic mosaic distribution of paternal mtDNA in the resulting progeny, including in the germline.