Mammalian cell growth dynamics in mitosis

https://elifesciences.org/articles/44700

Teemu P Miettinen, Joon Ho Kang, Lucy F Yang, Scott R Manalis

• The authors use a suspended microchannel resonator and protein synthesis assays to measure the accumulation of cell mass through the cell cycle, for single mammalian cells.
• For various animal cell types, the growth rate in prophase (the first stage of the cell cycle) is comparable to or larger than interphase (the phase where DNA is copied) growth rates. Growth is only stopped in the metaphase-to-anaphase transition. 
• The authors find that a range of mitotic arrest mechanisms inhibit cell growth. Their results counter the traditional idea that cell growth is negligible during mitosis.