The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

https://www.sciencedirect.com/science/article/pii/S1934590919300621

Vannini N, Campos V, Girotra M, Trachsel V, Rojas-Sutterlin S, Tratwal J, Ragusa S, Stefanidis E, Ryu D, Rainer PY, Nikitin G, Giger S, Li TY, Semilietof A, Oggier A, Yersin Y, Tauzin L, Pirinen E, Cheng WC, Ratajczak J, Canto C, Ehrbar M, Sizzano F, Petrova TV, Vanhecke D, Zhang L, Romero P, Nahimana A, Cherix S, Duchosal MA, Ho PC, Deplancke B, Coukos G, Auwerx J, Lutolf MP, Naveiras O

• Boosting NAD+ via dietary supplementation of nicotinamide riboside (NR) in mice
• Reduces mitochondrial activity in hematopoetic stem cells 
• Increases mitophagy in HSCs (determined in the mitoQC mouse)
• Reduces mitochondrial membrane potential (perhaps related to the increased mitophagy)
• Leading to increased asymmetric division of mitochondria (quantified by TMRM/mitochondrial mass) in HSCs, resulting in expansion of the hematopoetic progenitor compartment.
• NR supplementation enhanced survival and blood cell production following HSC transplantation.