Nuclear genetic regulation of the human mitochondrial transcriptome

https://elifesciences.org/articles/41927

Aminah T Ali, Lena Boehme, Guillermo Carbajosa, Vlad C Seitan, Kerrin S Small, Alan Hodgkinson

• The authors analyse >11k RNA sequencing libraries across 36 tissue types and investigate the variability in transcription of the mitochondrial genome
• The authors identify 64 nuclear genetic loci associated with expression of mitochondrially-encoded genes. 
• The authors replicate ~21% of associations with independent tissue-matched datasets.