NAD+ metabolism governs the proinflammatory senescence-associated secretome

https://www.nature.com/articles/s41556-019-0287-4

Nacarelli T, Lau L, Fukumoto T, Zundell J, Fatkhutdinov N, Wu S, Aird KM, Iwasaki O, Kossenkov AV, Schultz D, Noma KI, Baur JA, Schug Z, Tang HY, Speicher DW, David G, Zhang R

• THe authors show that the enzyme nicotinamide phosphoribosyltransferase (NAMPT), which is a rate-limiting enzyme of the NAD+ salvage pathway, is involved in the senesence-associated secretory phenotype (SASP), independent of the senesence-associated growth arrest.
• The signalling pathway the authors identify is promotes the SASP by enhancing glycolysis and mitochondrial respiration. 
• The tumour-promoting effects of SASP suggests that anti-ageing dietary NAD+ augmentation should be administered with care.