Wednesday, 28 February 2018

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics
Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA, Eckert A

  • Circadian regulation of dynamin-related protein 1 (DRP1), a key mitochondrial fission protein, results in daily cycles of fission and fusion which are essential for circadian oscillations in ATP production
  • Genetic and pharmacological abrogation of DRP1 activity abolished circadian network dynamics and eliminated circadian ATP production

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