Wednesday, 28 February 2018

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

http://www.cell.com/cell-metabolism/abstract/S1550-4131(18)30063-9
 
Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA, Eckert A

  • Circadian regulation of dynamin-related protein 1 (DRP1), a key mitochondrial fission protein, results in daily cycles of fission and fusion which are essential for circadian oscillations in ATP production
  • Genetic and pharmacological abrogation of DRP1 activity abolished circadian network dynamics and eliminated circadian ATP production

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