Cong-Hui Yao, Rencheng Wang, Yahui Wang, Che-Pei Kung, Jason D Weber, Gary J Patti
- The authors show that mouse fibroblasts increase oxidative phosphorylation by nearly x2, and mitochondrial coupling efficiency by ~30%, during proliferation. Both of these changes are supported by mitochondrial fusion.
- Modulating mitochondrial fusion through Mfn2 levels caused modulation in proliferation rate. Decreases in fusion decreased OXPHOS but not ATP levels.
- The authors suggest that cell proliferation requires increased OXPHOS supported by mitochondrial fusion.