Friday, 22 May 2015

Mechanisms linking mtDNA damage and aging


Milena Pinto and Carlos T. Moraes

A nice review on mitochondria and ageing, summarizing the links between ageing tissues and mtDNA turnover, damage and repair. A discussion is given on the free radical theory of ageing and its controversies, clonal expansion of mtDNA mutations, and the role of ROS damage/signalling in ageing. Finally, they comment on how mutations in mtDNA can lead to tissue failure.

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