Thursday, 12 February 2015

SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario

Luciana O. Almeida et al

SET is a protein that is accumulated in Alzheimer's disease and some types of cancer. It is hypothesized here that SET influences mitochondrial mechanisms.

In this paper they find that, in HEK293 cells overexpressing SET, levels of mitochondrial uncoupling proteins UCP2 and UCP3 are increased (uncoupling proteins allow for dissipation of the electrochemical gradient across the inner membrane of the mitochondrion). Cellular ATP content was decreased. Also, levels of mitochondrial fission were increased due to increased levels of the fission proteins Drp1 and Fis1.

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