Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
Cachexia is a condition often observed in cancer patients, associated with muscle wasting, frailty and weight loss. Although cachetic patients often ingest less food, they are also in a state of negative energy balance which cannot be corrected with nutritional supplementation. This has been linked to greater thermogenesis in brown fat tissue. The authors use a Lewis lung carcinoma murine model to identify a key secreted factor PTHrP which mediates muscle wasting in fat tissue.