Intramitochondrial transfer and engineering of mammalian mitochondrial genomes in yeast

https://www.sciencedirect.com/science/article/pii/S1567724918300370?via%3Dihub

Yoon YG, Koob MD

• The authors demonstrate that entire mouse mtDNA can be stably transferred to the mitochondrial network in yeast which have been depleted of their own native mtDNA.
• The yeast cells which contained the full mouse mtDNA genome, replicated the mouse mtDNA molecules without detectable sequence alterations or rearrangements.