Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

Shankar Mukherji, Erin K O'Shea

https://elifesciences.org/articles/02678

• Modelled the dynamics of organelle biogenesis, finding that fluctuations in organelle abundance depend strongly on the specific mechanisms that influence organelle number
• Model predicts the experimentally measured size of the Golgi apparatus and vacuole abundance fluctuations
• Work provides a general framework for exploring stochastic organelle biogenesis