Blanquer-Rosselló MD, Santandreu FM, Oliver J, Roca P, Valle A.
Leptin is a hormone
that regulates energy expenditure and suppresses food intake. The
concentration of leptin in the blood rises as body weight and fat
mass increase. Leptin is also involved in many other processes
including sex maturation, lactation, immune response and the
development of mammary gland. Leptin can increase cell proliferation
and inhibits apoptosis in breast cells.
In this paper they
investigate the link between leptin and metabolism in breast cancer
cells. Cancer cells must rewire cell metabolism to satisfy demands of
growth and proliferation. They analyze the effects of a physiological
dose of leptin in several features of cellular and mitochondrial
metabolism in MCF-7 breast cancer cells.
They find that
cellular ATP levels become more reliant on mitochondria in
leptin-treated cells and rates of glycolysis decreased.
Mitochondrial oxygen consumption increases, but no changes are seen
in mitochondrial volume density, respiratory chain proteins or proton
leak. ROS levels were decreased and autophagy was increased.
They conclude that
leptin ameliorates oxidative stress and increases mitochondrial ATP
production in breast cancer cells, which may benefit growth and
survival.
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