Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction

 http://www.sciencedirect.com/science/article/pii/S0891584914003384

They find that mitochondria of people with Mild Cognitive Impairment (MCI) (which is what you experience before Alzeimer's disease kicks in) have more MFN2. The expression levels of MFN2 are 1.8 fold higher than in control cells, meaning that the mitochondria of patients with MCI are more elongated.

There were decreased activities of complex I, III and IV in MCI cells, and ATP levels were lower in MCI cells. No difference in mitochondrial mass was observed.

Intensity of TMRM was decreased in MCI cells.